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  2<?xml version="1.0"?><Features nextValidID="14"><Feature recentID="0" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4112-4216" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="CmR" directionality="2" translationMW="25663.90" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5360-6019" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;cat&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to chloramphenicol&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="chloramphenicol acetyltransferase"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MEKKITGYTTVDISQWHRKEHFEAFQSVAQCTYNQTVQLDITAFLKTVKKNKHKFYPAFIHILARLMNAHPEFRMAMKDGELVIWDSVHPCYTVFHEQTETFSSLWSEYHDDFRQFLHIYSQDVACYGENLAYFPKGFIENMFFVSANPWVSFTSFDLNVANMDNFFAPVFTMGKYYTQGDKVLMPLAIQVHHAVCDGFHVGRMLNELQQYCDEWQGGA*"/></Q></Feature><Feature recentID="2" name="NeoR/KanR" directionality="2" translationMW="28979.67" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="3317-4111" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLLSSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEHQGLAPAELFARLKASMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF*"/></Q></Feature><Feature recentID="3" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="1575-2174" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MTEYKPTVRLATRDDVPRAVRTLAAAFADYPATRHTVDPDRHIERVTELQELFLTRVGLDIGKVWVADDGAAVAVWTTPESVEAGAVFAEIGPRMAELSGSRLAAQQQMEGLLAPHRPKEPAWFLATVGVSPDHQGKGLGSAVVLPGVEAAERAGVPAFLETSAPRNLPFYERLGFTVTADVEVPEGPRTWCMTRKPGA*"/></Q></Feature><Feature recentID="4" name="ccdB" directionality="2" translationMW="11706.79" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4713-5018" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;ccdB&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Plasmids containing the &lt;i&gt;ccdB&lt;/i&gt; gene cannot be propagated in standard &lt;i&gt;E. coli&lt;/i&gt; strains.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;CcdB, a bacterial toxin that poisons DNA gyrase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRMMTTDMASVPVSVIGEEVADLSHRENDIKNAINLMFWGI*"/></Q></Feature><Feature recentID="5" name="lac UV5 promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="6073-6079" color="#ffffff" type="standard"/><Segment range="6080-6097" color="#ffffff" type="standard"/><Segment name="-35" range="6098-6103" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli lac&lt;/i&gt; promoter with an &quot;up&quot; mutation&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2555-3143" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="T7 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4559-4577" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="hsp70 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1-239" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;Drosophila melanogaster&lt;/i&gt;&amp;nbsp;hsp70Bb promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1186-1515" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2177-2298" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="bGH poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1051-1162" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="Factor Xa site" directionality="1" translationMW="473.54" type="CDS" allowSegmentOverlaps="0" cleavageArrows="4593" consecutiveTranslationNumbering="1" maxRunOn="4869" maxFusedRunOn="4869" detectionMode="exactProteinMatch"><Segment range="4582-4593" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="IEGR"/></Q></Feature><Feature recentID="13" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4532-4548" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
  !¥<?xml version="1.0"?><Primers nextValidID="15"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/><Primer recentID="0" name="BGH-rev" sequence="TAGAAGGCACAGTCGAGG" description="Bovine growth hormone terminator, reverse primer. Also called BGH reverse"><BindingSite location="1044-1061" boundStrand="1" annealedBases="TAGAAGGCACAGTCGAGG" meltingTemperature="55"><Component hybridizedRange="1044-1061" bases="TAGAAGGCACAGTCGAGG"/></BindingSite><BindingSite simplified="1" location="1044-1061" boundStrand="1" annealedBases="TAGAAGGCACAGTCGAGG" meltingTemperature="55"><Component hybridizedRange="1044-1061" bases="TAGAAGGCACAGTCGAGG"/></BindingSite></Primer><Primer recentID="1" name="CAT-R" sequence="GCAACTGACTGAAATGCCTC" description="Chloramphenicol resistance gene, reverse primer"><BindingSite location="5933-5952" boundStrand="0" annealedBases="GCAACTGACTGAAATGCCTC" meltingTemperature="56"><Component hybridizedRange="5933-5952" bases="GCAACTGACTGAAATGCCTC"/></BindingSite><BindingSite simplified="1" location="5933-5952" boundStrand="0" annealedBases="GCAACTGACTGAAATGCCTC" meltingTemperature="56"><Component hybridizedRange="5933-5952" bases="GCAACTGACTGAAATGCCTC"/></BindingSite></Primer><Primer recentID="2" name="ccdB-fwd" sequence="GCATGATGACCACCGATATG" description="ccdB gene, forward primer"><BindingSite location="4814-4833" boundStrand="1" annealedBases="GCATGATGACCACCGATATG" meltingTemperature="55"><Component hybridizedRange="4814-4833" bases="GCATGATGACCACCGATATG"/></BindingSite><BindingSite simplified="1" location="4814-4833" boundStrand="1" annealedBases="GCATGATGACCACCGATATG" meltingTemperature="55"><Component hybridizedRange="4814-4833" bases="GCATGATGACCACCGATATG"/></BindingSite></Primer><Primer recentID="3" name="EBV-rev" sequence="GTGGTTTGTCCAAACTCATC" description="SV40 polyA terminator, reverse primer"><BindingSite location="2267-2286" boundStrand="0" annealedBases="GTGGTTTGTCCAAACTCATC" meltingTemperature="55"><Component hybridizedRange="2267-2286" bases="GTGGTTTGTCCAAACTCATC"/></BindingSite><BindingSite simplified="1" location="2267-2286" boundStrand="0" annealedBases="GTGGTTTGTCCAAACTCATC" meltingTemperature="55"><Component hybridizedRange="2267-2286" bases="GTGGTTTGTCCAAACTCATC"/></BindingSite></Primer><Primer recentID="4" name="L4440" sequence="AGCGAGTCAGTGAGCGAG" description="L4440 vector, forward primer"><BindingSite location="2444-2461" boundStrand="1" annealedBases="AGCGAGTCAGTGAGCGAG" meltingTemperature="58"><Component hybridizedRange="2444-2461" bases="AGCGAGTCAGTGAGCGAG"/></BindingSite><BindingSite simplified="1" location="2444-2461" boundStrand="1" annealedBases="AGCGAGTCAGTGAGCGAG" meltingTemperature="58"><Component hybridizedRange="2444-2461" bases="AGCGAGTCAGTGAGCGAG"/></BindingSite></Primer><Primer recentID="5" name="M13 Forward" sequence="TGTAAAACGACGGCCAGT" description="In lacZ gene. Also called M13-F20 or M13 (-21) Forward"><BindingSite location="4530-4547" boundStrand="0" annealedBases="TGTAAAACGACGGCCAGT" meltingTemperature="57"><Component hybridizedRange="4530-4547" bases="TGTAAAACGACGGCCAGT"/></BindingSite><BindingSite simplified="1" location="4530-4547" boundStrand="0" annealedBases="TGTAAAACGACGGCCAGT" meltingTemperature="57"><Component hybridizedRange="4530-4547" bases="TGTAAAACGACGGCCAGT"/></BindingSite></Primer><Primer recentID="6" name="M13/pUC Forward" sequence="CCCAGTCACGACGTTGTAAAACG" description="In lacZ gene"><BindingSite location="4516-4538" boundStrand="0" annealedBases="CCCAGTCACGACGTTGTAAAACG" meltingTemperature="61"><Component hybridizedRange="4516-4538" bases="CCCAGTCACGACGTTGTAAAACG"/></BindingSite><BindingSite simplified="1" location="4516-4538" boundStrand="0" annealedBases="CCCAGTCACGACGTTGTAAAACG" meltingTemperature="61"><Component hybridizedRange="4516-4538" bases="CCCAGTCACGACGTTGTAAAACG"/></BindingSite></Primer><Primer recentID="7" name="pBABE 3'" sequence="ACCCTAACTGACACACATTCC" description="SV40 enhancer, reverse primer for pBABE vectors"><BindingSite location="1180-1200" boundStrand="1" annealedBases="ACCCTAACTGACACACATTCC" meltingTemperature="56"><Component hybridizedRange="1180-1200" bases="ACCCTAACTGACACACATTCC"/></BindingSite><BindingSite simplified="1" location="1180-1200" boundStrand="1" annealedBases="ACCCTAACTGACACACATTCC" meltingTemperature="56"><Component hybridizedRange="1180-1200" bases="ACCCTAACTGACACACATTCC"/></BindingSite></Primer><Primer recentID="8" name="pBR322ori-F" sequence="GGGAAACGCCTGGTATCTTT" description="pBR322 origin, forward primer"><BindingSite location="2634-2653" boundStrand="1" annealedBases="GGGAAACGCCTGGTATCTTT" meltingTemperature="56"><Component hybridizedRange="2634-2653" bases="GGGAAACGCCTGGTATCTTT"/></BindingSite><BindingSite simplified="1" location="2634-2653" boundStrand="1" annealedBases="GGGAAACGCCTGGTATCTTT" meltingTemperature="56"><Component hybridizedRange="2634-2653" bases="GGGAAACGCCTGGTATCTTT"/></BindingSite></Primer><Primer recentID="9" name="pCasper-hs" sequence="GCAACTACTGAAATCTGCCAAG" description="Drosophila Hsp70 promoter, forward primer"><BindingSite location="185-206" boundStrand="0" annealedBases="GCAACTACTGAAATCTGCCAAG" meltingTemperature="57"><Component hybridizedRange="185-206" bases="GCAACTACTGAAATCTGCCAAG"/></BindingSite><BindingSite simplified="1" location="185-206" boundStrand="0" annealedBases="GCAACTACTGAAATCTGCCAAG" meltingTemperature="57"><Component hybridizedRange="185-206" bases="GCAACTACTGAAATCTGCCAAG"/></BindingSite></Primer><Primer recentID="10" name="Puro-F" sequence="GCAACCTCCCCTTCTACGAGC" description="Puromycin resistance gene, forward primer"><BindingSite location="2070-2090" boundStrand="0" annealedBases="GCAACCTCCCCTTCTACGAGC" meltingTemperature="60"><Component hybridizedRange="2070-2090" bases="GCAACCTCCCCTTCTACGAGC"/></BindingSite><BindingSite simplified="1" location="2070-2090" boundStrand="0" annealedBases="GCAACCTCCCCTTCTACGAGC" meltingTemperature="60"><Component hybridizedRange="2070-2090" bases="GCAACCTCCCCTTCTACGAGC"/></BindingSite></Primer><Primer recentID="11" name="Puro-R" sequence="GTGGGCTTGTACTCGGTCAT" description="Puromycin resistance gene, reverse primer. Also called puro-variant-R"><BindingSite location="1574-1593" boundStrand="1" annealedBases="GTGGGCTTGTACTCGGTCAT" meltingTemperature="59"><Component hybridizedRange="1574-1593" bases="GTGGGCTTGTACTCGGTCAT"/></BindingSite><BindingSite simplified="1" location="1574-1593" boundStrand="1" annealedBases="GTGGGCTTGTACTCGGTCAT" meltingTemperature="59"><Component hybridizedRange="1574-1593" bases="GTGGGCTTGTACTCGGTCAT"/></BindingSite></Primer><Primer recentID="12" name="SV40pA-R" sequence="GAAATTTGTGATGCTATTGC" description="SV40 polyA, reverse primer"><BindingSite location="2213-2232" boundStrand="1" annealedBases="GAAATTTGTGATGCTATTGC" meltingTemperature="52"><Component hybridizedRange="2213-2232" bases="GAAATTTGTGATGCTATTGC"/></BindingSite><BindingSite simplified="1" location="2213-2232" boundStrand="1" annealedBases="GAAATTTGTGATGCTATTGC" meltingTemperature="52"><Component hybridizedRange="2213-2232" bases="GAAATTTGTGATGCTATTGC"/></BindingSite></Primer><Primer recentID="13" name="SV40pro-F" sequence="TATTTATGCAGAGGCCGAGG" description="SV40 promoter/origin, forward primer"><BindingSite location="1427-1446" boundStrand="0" annealedBases="TATTTATGCAGAGGCCGAGG" meltingTemperature="57"><Component hybridizedRange="1427-1446" bases="TATTTATGCAGAGGCCGAGG"/></BindingSite><BindingSite location="1450-1461" boundStrand="1" annealedBases="CAGAGGCCGAGG" meltingTemperature="51"><Component bases="TATTTATG"/><Component hybridizedRange="1450-1461" bases="CAGAGGCCGAGG"/></BindingSite><BindingSite simplified="1" location="1427-1446" boundStrand="0" annealedBases="TATTTATGCAGAGGCCGAGG" meltingTemperature="57"><Component hybridizedRange="1427-1446" bases="TATTTATGCAGAGGCCGAGG"/></BindingSite><BindingSite simplified="1" location="1450-1461" boundStrand="1" annealedBases="CAGAGGCCGAGG" meltingTemperature="51"><Component bases="TATTTATG"/><Component hybridizedRange="1450-1461" bases="CAGAGGCCGAGG"/></BindingSite></Primer><Primer recentID="14" name="T7" sequence="TAATACGACTCACTATAGGG" description="T7 promoter, forward primer"><BindingSite location="4558-4577" boundStrand="0" annealedBases="TAATACGACTCACTATAGGG" meltingTemperature="50"><Component hybridizedRange="4558-4577" bases="TAATACGACTCACTATAGGG"/></BindingSite><BindingSite simplified="1" location="4558-4577" boundStrand="0" annealedBases="TAATACGACTCACTATAGGG" meltingTemperature="50"><Component hybridizedRange="4558-4577" bases="TAATACGACTCACTATAGGG"/></BindingSite></Primer></Primers>
  Ã<Notes>
<UUID>db66721b-9e6b-438a-abef-7510f2adb42f</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pBait</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Description>Bait plasmid for PROBER (empty backbone encoding replaceable ccdB cassette).</Description>
<Created UTC="14:53:46">2021.7.15</Created>
<LastModified UTC="14:53:46">2021.7.15</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
<References>
<Reference journal="Unpublished" title="PROBER Identifies Proteins Associated with Sequence-Specific DNA in Living Cells" type="Journal Article" journalName="Unpublished"/>
</References>
</Notes>
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   )<?xml version="1.0"?><CustomEnzymeSets/>
